产品索引
        
Trp-p8;Long transient receptor potential channel 6;Transient receptor potential p8
        
产品数据 
        

          

            

              

                货号
              
              
LPMA10234
              

                文献
              
              

                详细请查看官网 
              
            

            

              

                产品名称
              
              
Anti TRPM8 mouse monoclonal antibody
            
            

              

                中文名称
              
              
 TRPM8 小鼠单克隆抗体
            
            

              
规格
              
100ug
              
适应种属
              
Human
            
            

              

                纯化方法
              
              
Protein G purified from mice ascites
              

                UniProt ID
              
              

                Q7Z2W7
              
            
            

              

                浓度
              
              
1mg/ml
              

                宿主
              
              
Mouse
            
            

              

                克隆性
              
              
Monoclonal
              

                亚型
              
              
IgG1 
            
            

              

                免疫原
              
              
Peptide 2: Ac-SSNKSSLCQGILRQNEQRWR-
CONH2  
              

                分子量
              
              
128 kDa
            
            

              

                验证应用
              
              
Elisa,IHC
            
            

              

                验证应用
              
              
Liquid
            
            

              

                建议稀释比例
              
              
Elisa:1:1000~5000,IHC:1:50~100
              

                存储条件
              
              
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
            
            

              

                偶联物
              
              
Unconjugate 
              

                储存溶液
              
              
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol. 
            
            

              

                运输条件
              
              

                所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。
              
            
            

              

                注意事项
              
              

                该产品仅供科研使用
              
            
          
        
        

        
背景介绍
        
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

        
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