IL33 小鼠单克隆抗体
产品名称： IL33 小鼠单克隆抗体
英文名称： IL33 Mouse monoclonal antibody
产品编号： LPMA10237
产品价格： null
产品产地： 中国
品牌商标： Ablepscience
更新时间： null
使用范围：
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- 邮编 : 430075
- 所在区域 : 湖北
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- 邮箱 : sale@apescience.cn;3055949650@qq.com
产品索引
IL-1F11，NF-HEV，C9orf26
产品数据
货号 LPMA10237 文献 详细请查看官网 产品名称 Anti IL33 mouse monoclonal antibody 中文名称 IL33 小鼠单克隆抗体 规格 100ug 适应种属 Human 纯化方法 Protein G purified from mice ascites UniProt ID O95760 浓度 1mg/ml 宿主 Mouse 克隆性 Monoclonal 亚型 IgG1 免疫原 AFGISGVQKYTRALHDS-Cys (peptide corresponding to aa95-111 of IL33) 分子量 31 kDa 验证应用 Elisa,IHC 验证应用 Liquid 建议稀释比例 Elisa:1:1000~5000,IHC:1:50~100 存储条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 °C for frequent use. Store at -20 to -80 °C for twelve months from the date of receipt. 偶联物 Unconjugate 储存溶液 PBS, pH7.4, containing 0.05% proclin300, 50% glycerol. 运输条件 所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。 注意事项 该产品仅供科研使用
背景介绍
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).