periostin 小鼠单克隆抗体
产品名称： periostin 小鼠单克隆抗体
英文名称： periostin Mouse monoclonal antibody
产品编号： LPMA10029
产品价格： null
产品产地： 中国
品牌商标： Ablepscience
更新时间： null
使用范围：
- 联系人 :
- 地址 : 武汉东湖新技术开发区汤逊湖北路36号新能源研发基地3号楼3层314室
- 邮编 : 430075
- 所在区域 : 湖北
- 电话 : 027-818*5800 点击查看
- 传真 : 点击查看
- 邮箱 : sale@apescience.cn;3055949650@qq.com
产品索引
PN, Osteoblast-specific factor 2, OSF-2
产品数据
货号 LPMA10029 文献 详细请查看官网 产品名称 Anti periostin mouse monoclonal antibody 中文名称 periostin 小鼠单克隆抗体 规格 100ug 适应种属 Human 纯化方法 Protein G purified from mice ascites UniProt ID Q15063 浓度 1mg/ml 宿主 Mouse 克隆性 Monoclonal 亚型 IgG 1 免疫原 Recombinant protein of full length human periostin 分子量 94 kDa 验证应用 Elisa,WB,IHC 验证应用 Liquid 建议稀释比例 Elisa:1~1000-5000;WB:1:1000~4000,IHC:1:50~100 存储条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 °C for frequent use. Store at -20 to -80 °C for twelve months from the date of receipt. 偶联物 Unconjugate 储存溶液 PBS, pH7.4, containing 0.05% proclin300, 50% glycerol. 运输条件 所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。 注意事项 该产品仅供科研使用
背景介绍
Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. Periostinis a secreted extracellular matrix protein that was originally identified in cells from the mesenchymal lineage (osteoblasts, osteoblast-derived cells, the periodontal ligament, andperiosteum). It has been associated with theepithelial-mesenchymal transitionin cancer and with the differentiation of mesenchyme in the developing heart.This protein shares a homology with fasciclin I, a secreted cell adhesion molecule found in insects.In many cancers,periostinbinds tointegrinson cancer cells, activating theAkt/PKB-andFAK-mediatedsignaling pathways. This leads to increased cell survival, invasion,angiogenesis,metastasis, and the epithelial-mesenchymal transition.In humans and mice,periostinundergoes alternative splicing in its C-terminal region, resulting in specificisoformsthat can be observed in a broad range of cancers such as pancreatic, colon, and breast cancer.Whileperiostinplays a wide variety of roles in tissue development along with disease, its function in tissue remodeling as a response to injury is a common underlying role in these different mechanisms.Periostinis transiently upregulated during cell fate changes, whether they are related to alterations in physiology or to pathological changes. It influencesextracellular matrixrestructuring, tissue remodeling, and the epithelial-mesenchymal transition, all of which can be related to tissue healing, development, and disease. Thus, it functions as a mediator, balancing appropriate and inappropriate responses to tissue damage.