产品索引
        

        
产品数据 
        

          

            

              

                货号
              
              
LPA26151
              

                文献
              
              

                详细请查看官网 
              
            

            

              

                产品名称
              
              
CD146 mouse Monoclonal Antibody(PT0278)
            
            

              

                中文名称
              
              
CD146 小鼠单克隆抗体(PT0278)
            
            

              
规格
              
100ug
              
适应种属
              
Human
            
            

              

                纯化方法
              
              
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
              

                UniProt ID
              
              

                
              
            
            

              

                浓度
              
              
1mg/ml
              

                宿主
              
              
Mouse
            
            

              

                克隆性
              
              
Monoclonal
              

                亚型
              
              

            
            

              

                免疫原
              
              
Synthesized peptide derived from human CD146 
              

                分子量
              
              

            
            

              

                验证应用
              
              
IHC-p,WB
            
            

              

                验证应用
              
              
Liquid
            
            

              

                建议稀释比例
              
              
IHC-p 1:100-300，WB 1:500-2000
              

                存储条件
              
              
-20°C/1 year
            
            

              

                偶联物
              
              
Unconjugated 
              

                储存溶液
              
              
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. 
            
            

              

                运输条件
              
              

                所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。
              
            
            

              

                注意事项
              
              

                该产品仅供科研使用
              
            
          
        
        

        
背景介绍
        
function:Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.,

        
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