C10orf81 is a 462 amino acid protein that contains one PH domain and exists as five alternatively spliced isoforms. The gene encoding C10orf81 maps to human chromosome 10q25.3. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth diseas, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.