产品索引
        
Proliferation marker protein Ki-67
        
产品数据 
        

          

            

              

                货号
              
              
LPMA10255
              

                文献
              
              

                详细请查看官网 
              
            

            

              

                产品名称
              
              
Anti Ki67 mouse monoclonal antibody
            
            

              

                中文名称
              
              
 Ki67 小鼠单克隆抗体
            
            

              
规格
              
100ug
              
适应种属
              
Human
            
            

              

                纯化方法
              
              
Protein G purified from mice ascites
              

                UniProt ID
              
              

                P46013
              
            
            

              

                浓度
              
              
1mg/ml
              

                宿主
              
              
Mouse
            
            

              

                克隆性
              
              
Monoclonal
              

                亚型
              
              
IgG1
            
            

              

                免疫原
              
              
 aa3088-3235:DIGSEFGISLRSRRQNKTEAEQQITEVFVLAERIEINRNEKKPMKTSPEMDIQNPDDGARKPIPRDKVT
ENKRCLRSARQNESSQPKVAEESGGQKSAKVLMQNQKGKGEAGNSDSMCLRSRKTKSQPAASTLESKSVQRVTRSVKRCA
ENPKK 
              

                分子量
              
              
359 kDa
            
            

              

                验证应用
              
              
Elisa,IHC,IF
            
            

              

                验证应用
              
              
Liquid
            
            

              

                建议稀释比例
              
              
Elisa:1:1000~5000;IHC:1:100~400;IF:1:50~200
              

                存储条件
              
              
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
            
            

              

                偶联物
              
              
Unconjugate 
              

                储存溶液
              
              
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol. 
            
            

              

                运输条件
              
              

                所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。
              
            
            

              

                注意事项
              
              

                该产品仅供科研使用
              
            
          
        
        

        
背景介绍
        
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable)

        
          点击查看产品官网详情 > > >